New research has raised fresh concerns for people who rely on proton pump inhibitors (PPIs), a widely used class of acid reflux medications. According to the findings, long-term PPI use may increase the risk of developing dementia by up to 33%, adding to previous warnings linking the drugs to strokes and kidney disease. While millions depend on PPIs for relief from severe reflux symptoms, researchers stress that the study shows an association—not definitive proof. Even so, the growing body of evidence surrounding long-term risks has prompted experts to urge caution, especially for people who take these medications daily for extended periods.
Acid reflux occurs when stomach acid flows back into the esophagus, often after meals or while lying down, causing burning discomfort and, in some cases, damage. Chronic reflux can develop into gastroesophageal reflux disease (GERD), which affects nearly 20% of Americans and more than 40% of adults in the UK. PPIs such as omeprazole, esomeprazole, and lansoprazole remain among the most commonly prescribed treatments. They work by reducing stomach acid production, easing symptoms and helping the esophagus and stomach lining heal. Their effectiveness has made them a long-term solution for many, but the new findings raise questions about whether extended use may have hidden consequences.
Health agencies have previously flagged potential dangers associated with prolonged PPI use. The U.S. Food and Drug Administration (FDA) has warned of increased risks of kidney disease, bone fractures, and infections like C. difficile. A 2019 BMJ study even reported a higher likelihood of premature death among long-term users. The latest research, published in Neurology by the University of Minnesota, examined whether these medications could also raise dementia risk. While the study cannot prove causation, researchers note that PPI users often have other health issues that may influence cognitive decline.
Experts stress that the findings should not trigger alarm but rather encourage informed decisions. Patients who depend on PPIs should consult healthcare providers before making any changes, as these medications remain essential for many people with severe reflux, ulcers, or limited treatment alternatives.
